上級研究員の紹介

プロフィール

氏名：
Lassalle Michael Wolfgang（ラサ-ル・ミヒャエル・ウルフガング）
研究の拠点：
無細胞生命科学工学研究センター
研究分野：
タンパク質の実時間の進化
職歴
1998年08月日本学術振興会　神戸大学　大学院自然科学研究員
高圧NMR による研究
2000年08月カネボウ株式会社 研究開発業務　研究員
2002年04月富士レビオ株式会社　先端研究部門　先端研究部　研究員
2003年10月科学技術振興機構 戦略的創造研究推進事業（ERATO）
2008年09月愛媛大学上級研究員センター　上級研究員
現在に至る
学歴
1989年09月Diplom-Chemiker Vorpruefung
1991年12月Diploma in Chemistry
1994年02月Ph.D.
受賞歴
1995年01月Scholarship “Stiftung Stipendien-Fonds des Verbandes der Chemischen Industrie e.V.”
1998年09月Scholarship “Japan Society for the Promotion of Science”

研究業績（論文等）>>

研究紹介

In vitro evolution and design of protein function is a common tool in protein engineering. However, a great many of the publications are suffering from limited analytical characterization to the consequences of sequence modifications at the molecular level. I shall try to overcome this deficit by applying systematically a variety of techniques. ”Evolution in the test tube” associated with proper characterization of the individual structural and functional alterations of the protein should allow for a better understanding of the factors governing the transformation from a mesophilic to a hyperthermophilic state.

今後の抱負

It is likely that different states of the native, intermediate, and unfolded example possess individual biological functions (multiple structure/function hypothesis-Lassalle). However, the factors transforming a protein into a biological active state (not the lowest energy conformation!) are not well known. In my group we shall focus to determine those factors.

In the laboratory of Prof. Akasaka we showed for the oncogene c-Myb that mutations in the cavity are leading to functional changes.

Consequently, for understanding the protein function not only the amino-acids in the vicinity of the binding domain but also those amino-acids that are important for the dynamic properties of the functional domain have to be taken into account.

In our recent paper we established that only such a strategy leads to a good understanding of human cardiac disease.

Hopefully, in the future biological active proteins can be designed from scratch giving us the potential to protect those who we love most.

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